Thursday, October 25, 2007

Propylthiouracil in Pregnancy

Question
What is the maximum dose of propylthiouracil (PTU) that one can prescribe to a pregnant patient?

"...
Adverse reactions may occur with these medications. Approximately 10% of patients will experience a skin rash. The most rare complication is agranulocytosis, which occurs in approximately 1 in 200 pregnancies. This is reversible once the medication is discontinued. A baseline white blood cell count is recommended. Both drugs cross the placenta, but PTU does so less readily than methimazole. Aplasia cutis was described in 20 infants exposed in utero to methimazole. The risk of this occurrence when using this medication is unknown, but no such adverse reactions to the fetus have been described with the use of PTU. This is a reason why PTU is preferred over methimazole.
..."

taken from medscape.com

1 in 200 pregnancies is not that rare loh... Will you take the risk?

2 comments:

The children's book cove said...

Hi ,
R u planning for 2nd baby ?
JEnny

Hann Hann said...

Me? no. I'm too young for marriage, not to mention babies. I just graduated from babyhood myself some 5months ago. hahahaha.

ok, serious. My mummy was planning to give me a silbing who will 2 years younger than me, but i think they're shelving the plan now since Mummy is not well.